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Hemoglobinopathies

A letter means that the baby has positive results and these are presumptive of sickle cell disease, other hemoglobinopathy, or trait.

A. Presumptive Sickle Disease:

  • FS Presumed sickle cell disease
  • FSC, FCS Presumed sickle-hemoglobin C disease
  • FSE Presumed sickle-hemoglobin E disease
  • FSA Presumed sickle-β+-thalassemia

B. Non-Sickle Hemoglobinopathies:

  • FC Presumed hemoglobin C disease
  • FCA Presumed hemoglobin C-β+-thalassemia
  • FE Presumed hemoglobin E disease
  • F Fetal hemoglobin only - inconclusive

C. Hemoglobinopathy Trait:

  • FAS Presumed sickle trait
  • AFS, ASF Presumed sickle trait; sickle disease not entirely excluded
  • FAC Presumed hemoglobin C trait
  • FAE Presumed hemoglobin E trait
  • FAG Presumed hemoglobin G trait
  • FAD Presumed hemoglobin D trait
  • FA+Barts Presumed alpha-thalassemia trait (may be seen in conjunction with other traits and disease states)
  • FA + unidentified Presumed trait for unidentified hemoglobin
  • FA + fast Presumed trait for unidentified fast hemoglobin

D. Other: AF


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A. Presumptive Sickle Disease – please see below. Penicillin Prophylaxis is indicated.

  • FS Presumed sickle cell disease
  • FSC, FCS Presumed sickle-hemoglobin C disease
  • FSE Presumed sickle-hemoglobin E disease
  • FSA Presumed sickle-β+-thalassemia

Steps:

  1. Contact parent/guardian to check on the health of the infant, and to explain these results.
  2. Physicians please refer to attached newborn screening information sheet for interpretation of results.
  3. Send whole blood for confirmatory electrophoresis at 2-3 months of age. Please fax a copy of the results to health department at 501-682-6686.
  4. Penicillin prophylaxis should be started no later than 2 months of age.
  5. It is recommended that primary care physicians refer infants to the Arkansas Children's Hospital Comprehensive Sickle Cell Clinic. Please call 364-1076 to set up an appointment.

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B. Non-Sickle Hemoglobinopathies. No Antibiotic Prophylaxis is indicated.

  • FC Presumed hemoglobin C disease
  • FCA Presumed hemoglobin C-β+-thalassemia
  • FE Presumed hemoglobin E disease
  • F Fetal hemoglobin only - inconclusive

Steps:

  1. Contact parent/guardian to check on the health of the infant, and to explain these results.
  2. Refer to attached newborn screening information sheet for interpretation of results.
  3. Send whole blood for confirmatory electrophoresis at 2-3 months of age. Please fax a copy of the results to health department at 501-682-6686.
  4. It is recommended that primary care physicians refer infants to the Arkansas Children's Hospital Comprehensive Sickle Cell Clinic. Please call 364-1076 to set up an appointment.

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C. Hemoglobinopathy Trait. No Antibiotic Prophylaxis is indicated.

  • FAS Presumed sickle trait
  • AFS, ASF Presumed sickle trait; sickle disease not entirely excluded
  • FAC Presumed hemoglobin C trait
  • FAE Presumed hemoglobin E trait
  • FAG Presumed hemoglobin G trait
  • FAD Presumed hemoglobin D trait
  • FA+Barts Presumed alpha-thalassemia trait (may be seen in conjunction with other traits and disease states)
  • FA + unidentified Presumed trait for unidentified hemoglobin
  • FA + fast Presumed trait for unidentified fast hemoglobin

Steps:

  1. The health department notifies the primary care provider by mail of the result, and encloses the interpretation sheet for hemoglobinopathy screening results.
  2. The health department contacts the parent/guardian by mail to inform them of results and send a parent information sheet to them. For any questions, please contact the health department at 1-866-769-9043 OR call 501-364-4050 to speak with the Newborn Screening Coordinator.
  3. For babies who received a blood transfusion prior to collection of their newborn screening, please refer to the health department letter for specific follow-up or contact the health department at 1-866-769-9034.

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D. AF: If found within 3-4 months of a transfusion, this result is inconclusive.

Otherwise, the result is presumed to be normal.


For any questions, please contact the health department at 1-866-769-9043 OR call 501-364-4050 to speak with the Newborn Screening Coordinator.

For more information, regarding Sickle Cell Trait, please see information at the ADH website.

For more information, regarding Alpha Thalassemia Trait, please see information at the ADH website.

For more information, regarding Trait for Unidentified Hemoglobin, please see information at the ADH website.

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