Vascular Anomalies Research

The Center for Investigation of Congenital Aberrancies in Vascular Development at the Arkansas Children's Hospital Research Institute (ACHRI) was established in 2008. The center was created to open a dedicated molecular and biology laboratory to the investigation of vascular anomalies and conduct pilot work on in vitro and in vivo experimental models of disease. In the process, the laboratory has successfully isolated Hemangioma stem cells, explored various molecular markers, and grown various vascular anomalies in nude mice and tissue culture. Our team has presented this work at international scientific conferences and have several manuscripts in progress. Dr. Gresham Richter serves as the Research Director of the Center for Investigation of Congenital Aberrancies in Vascular Development and he is also one of the Pediatric Otolaryngologist on the Vascular Anomalies Team. Jessica Boswell, CRS, serves the Vascular Anomalies Team and Research Center as Clinical Research and Project Coordinator. Our facility occupies 650 ft 2 that is fully operational to conduct the entire spectrum of laboratory techniques including, immunohistochemistry, Western blotting, Northern blotting, RTPCR, tissue culture, and animal experiments. Local institutional intramural funding has supported the initial equipment acquisition and pilot projects.

Some of the awards our research team has won are as follows:

William P. Potsic Basic Science Award for Outstanding Achievement in the Field of Pediatric Otolaryngology from the American Society of Pediatric Otolaryngology

  • 2011 First Place-Dr. Dai, "Enos Protein Expressions is Decreased in Involuting Hemangioma's"
  • 2011 Second Place-Dr. Hou, "Novel In-Vivo Model for Human Lymphatic Malformations"

Their achievement is the first time in the award program's history that researchers from the same institute were awarded first and second places in the same year.