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Dr. Tackett’s laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. He uses a suite of techniques in studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, and biochemical and proteomic approaches for analyses of protein complexes and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. In addition to melanoma work, Dr. Tackett’s team develops new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone-modifying proteins.