Dr. Rose’s research interests include oxidative stress and mitochondrial abnormalities in autism spectrum disorders (ASD) and the role of environmental factors in these abnormalities. Dr. Rose’s research builds upon her predoctoral studies with Dr. S. Jill James which focused on systemic glutathione redox imbalance in ASD and its association with oxidative stress and mitochondrial dysfunction. Working together with Dr. Richard E. Frye and his team at ACRI, she is applying the state-of-the-art Seahorse extracellular flux technology to autism to understand the relationship between oxidative stress, environmental exposures, and mitochondrial dysfunction using immune cells from children with ASD and unaffected control children.
Dr. Rose is the 2016 co-recipient of the Marion B. Lyon New Scientist Development Award for her project, An In Vitro Model of Mitochondrial-Dependent Environmentally Triggered Disease. Dr. Rose is studying the ability of diverse environmental exposures to cause adaptive changes in mitochondrial function that persist and lead to increased vulnerability to mitochondrial dysfunction and identifying the molecular changes responsible for adaptive changes in mitochondrial function. Understanding the molecular mechanisms of adaptive changes in mitochondrial function that cells possess is essential for understanding the pathology of the mitochondrial response to environmental stress and is important for developing therapies to target or prevent environmentally induced mitochondrial dysfunction.
Dr. Rose’s passion and eagerness to better understand autism is driven by her very personal family connection to autism.