Flu Vaccine Resources & Information >

Search
Arkansas Children's
Care
Discover
Give
My Arkansas Children's
Close menu
Care Discover Give Search En español My Arkansas Children's

Care

Get Care
  • Request an Appointment
  • Find Locations
  • Find Doctors
  • Programs and Services
  • Clinical Trials
  • Regional Care Center
  • Contact Us
Manage Care
  • Prepare for Your Visit
  • Accommodations
  • Insurance
  • Online Bill Pay
  • Medical Records
  • Access MyChart
  • Arkansas Children's App
For Healthcare Professionals
  • Arkansas Children's Care Network
  • Refer a Patient
  • Healthy Planet
  • Residency and Fellowship Programs
  • Continuing Education
  • Careers
  • Research Institute
  • Other Resources
Emergency Care
  • Find an Emergency Room
  • Emergency Preparedness

Get Care

  • Request an Appointment
  • Find Locations
  • Find Doctors
  • Programs and Services
  • Clinical Trials
  • Regional Care Center
  • Contact Us
Happy little girl wearing a yellow bow.

Ranked nationally in pediatric care.

Arkansas Children's provides right-sized care for your child. U.S. News & World Report has ranked Arkansas Children's in seven specialties for 2022-2023.

Manage Care

  • Prepare for Your Visit
  • Accommodations
  • Insurance
  • Online Bill Pay
  • Medical Records
  • Access MyChart
  • Arkansas Children's App
Father on tablet accessing MyChart

It's easier than ever to sign up for MyChart.

Sign up online to quickly and easily manage your child's medical information and connect with us whenever you need.

For Healthcare Professionals

  • Arkansas Children's Care Network
  • Refer a Patient
  • Healthy Planet
  • Residency and Fellowship Programs
  • Continuing Education
  • Careers
  • Research Institute
  • Other Resources
Doctor holding a baby

Need to refer a patient?

We're focused on improving child health through exceptional patient care, groundbreaking research, continuing education, and outreach and prevention.

Emergency Care

  • Find an Emergency Room
  • Emergency Preparedness
Family leaving emergency department

When it comes to your child, every emergency is a big deal.

Our ERs are staffed 24/7 with doctors, nurses and staff who know kids best – all trained to deliver right-sized care for your child in a safe environment.

Discover

Programs and Services
View all specialties >
  • General Pediatric Clinic
  • Primary Care Clinic
  • Cardiology
  • Neurosciences
  • Hematology and Oncology
  • Ear, Nose, and Throat
  • Doctors
  • Locations
  • Services and Support
Family Resources
View all resources >
  • Arkansas Children's App
  • Blog
  • Patient Stories
  • "Live. Learn. Play." Podcast
  • Child Life and Education
  • Family Support Services
  • Social Work
  • Resource Connect
Health at Home
  • Symptom Checker
  • Community Outreach
  • Natural Wonders
  • Child Safety and Injury Prevention
  • "Live. Learn. Play." Podcast
  • The Center for Good Mourning
About Arkansas Children's
  • About Arkansas Children's
  • Mission, Vision, and Values
  • Our Leadership Team
  • Awards and Recognition
  • Angel One
  • Patient Safety
  • News
Research
  • About ACRI
  • Research Programs and Centers
  • Our Researchers
  • Clinical Trials
  • Resources for Researchers
  • Summer Science Program
For Healthcare Professionals
  • Arkansas Children's Care Network
  • Healthy Planet Link
  • Referring Physician Resources
  • Nursing Resources
  • Education and Training
  • "The Doc Talk" Podcast
Work With Us
  • Careers
  • Students and Residents
  • Volunteer
  • Family Advisor Program
  • Job Shadowing

Programs and Services

View all specialties >
  • General Pediatric Clinic
  • Primary Care Clinic
  • Cardiology
  • Neurosciences
  • Hematology and Oncology
  • Ear, Nose, and Throat
  • Doctors
  • Locations
  • Services and Support
Dr. Veerapandiyan with patient

Expert care for your child.

Arkansas Children's provides right-sized care for your child. U.S. News & World Report has ranked Arkansas Children's in seven specialties for 2022-2023.

Family Resources

View all resources >
  • Arkansas Children's App
  • Blog
  • Patient Stories
  • "Live. Learn. Play." Podcast
  • Child Life and Education
  • Family Support Services
  • Social Work
  • Resource Connect
Family laughing and sitting on stairs

Looking for resources for your family?

Find health tips, patient stories, and news you can use to champion children.

Health at Home

  • Symptom Checker
  • Community Outreach
  • Natural Wonders
  • Child Safety and Injury Prevention
  • "Live. Learn. Play." Podcast
  • The Center for Good Mourning
Patient with mask

Support from the comfort of your home.

Our flu resources and education information help parents and families provide effective care at home.

About Arkansas Children's

  • About Arkansas Children's
  • Mission, Vision, and Values
  • Our Leadership Team
  • Awards and Recognition
  • Angel One
  • Patient Safety
  • News
Girl on playground

Children are at the center of everything we do.

We are dedicated to caring for children, allowing us to uniquely shape the landscape of pediatric care in Arkansas.

Research

  • About ACRI
  • Research Programs and Centers
  • Our Researchers
  • Clinical Trials
  • Resources for Researchers
  • Summer Science Program
Nurse measuring a baby's head

Transforming discovery to care.

Our researchers are driven by their limitless curiosity to discover new and better ways to make these children better today and healthier tomorrow.

For Healthcare Professionals

  • Arkansas Children's Care Network
  • Healthy Planet Link
  • Referring Physician Resources
  • Nursing Resources
  • Education and Training
  • "The Doc Talk" Podcast
Doctor holding a baby

Need to refer a patient?

We're focused on improving child health through exceptional patient care, groundbreaking research, continuing education, and outreach and prevention.

Work With Us

  • Careers
  • Students and Residents
  • Volunteer
  • Family Advisor Program
  • Job Shadowing
Nurse with patient

Looking to make a difference?

Then we're looking for you! Work at a place where you can change lives...including your own.

Give

Arkansas Children's Foundation
  • Donate Now
  • About the Foundation
  • Ways to Give
  • Planned Giving
  • Donate Toys and Gifts
Volunteer
  • Ways to Volunteer
  • Special Programs
  • Volunteering in Little Rock
  • Volunteering in Springdale
  • Donate Toys and Gifts
Government Relations
  • What is Government Relations?

Arkansas Children's Foundation

  • Donate Now
  • About the Foundation
  • Ways to Give
  • Planned Giving
  • Donate Toys and Gifts
Mother with two children

Every little bit matters.

When you give to Arkansas Children's, you help deliver on our promise of a better today and a healthier tomorrow for the children of Arkansas and beyond

Volunteer

  • Ways to Volunteer
  • Special Programs
  • Volunteering in Little Rock
  • Volunteering in Springdale
  • Donate Toys and Gifts
Group of volunteers

Become a volunteer at Arkansas Children's.

The gift of time is one of the most precious gifts you can give. You can make a difference in the life of a sick child.

Government Relations

  • What is Government Relations?
Girl on playground

Join our Grassroots Organization

Support and participate in this advocacy effort on behalf of Arkansas’ youth and our organization.

Recommended

  • MyChart
  • Programs and Services
  • Pay Your Bill
  • En español
  • Personalize your website experience...Personalize your experience
Green Arrow

Hello.

Customize your experience.

Contact Us

Arkansas Children's Hospital
General Information: 501-364-1100

Arkansas Children's Northwest
General Information: 479-725-6800

Recommended

  • Contact Us
  • MyChart
  • Programs and Services
  • Pay Your Bill
  • En español
Close onboarding Close personalization modal
Loading
< Researchers

Timothy R. Koscik, Ph.D.

Associate Professor, Neurology, Department of Pediatrics

Research Overview

Timothy Koscik, Ph.D.Neuroscience research has largely focused on the microscale of neurons and molecular biology or the macroscale of brain regions and networks. However, the organizational principles in between these two extremes at the mesoscale are the critical determinants of brain function (and dysfunction). For example, the layered organization of neurons in the cerebral cortex determines information processing capabilities, and variations in this layered organization determines functional localization throughout the brain. However, technological limitations, that is, the need to see tiny structures across vast areas, have limited our understanding of mesoscale neuroanatomy and the contributions of the mesoscale to neurodevelopment and neurodegenerative disease.

Dr. Koscik’s research is focused on understanding mesoscale neuroanatomy, using ultra-high-resolution neuroimaging in postmortem human brains. While typical neuroimaging research explores resolution of 1 mm3, studying the laminar architecture of the cerebral cortex requires whole brain imaging approximately 300 to 1,000 times more detailed around 150 microns. Dr. Koscik’s team is combining advances in scan acquisition, image processing, and deep learning technologies to explore mesoscale neuroanatomy in higher detail and with higher throughput than previously possible. The ultimate goal of this research is to provide novel insight into mesoscale neuroanatomical features, such as cortical laminar architecture, that simultaneously provide us with our fantastic abilities as humans, but where subtle perturbations may contribute to neurological, psychiatric, and neurodegenerative disease.

In line with this idea, emerging evidence suggests that maladaptive development of the cortical lamina may drive the pathology of Huntington’s disease (HD). Early in HD, neurons fail to migrate into normal laminar patterns in the cortex, resulting in hyperexcitability in cortical circuits. Through a subsequent cascade of events this hyperexcitability may cause downstream neurodegeneration through excitotoxic pathways. A goal of Dr. Koscik’s current research is to explore maladaptive laminar development in HD and explore how this mediates HD pathology. Ultimately, a better understanding of the cascading, neurodevelopmental, pathological mechanisms in HD will provide the knowledge necessary to guide therapeutic agents to appropriate neuroanatomical targets and to deliver these therapeutics to developmental stages that are appropriate for rectifying the underlying pathology.

Phone: 501-364-2768

  • About Us
  • Billing, Insurance & Financial Assistance
  • Careers
  • Community Engagement
  • Research
  • For Healthcare Professionals
  • Family Resource Center
  • Foundation
  • Government Relations
  • Volunteer
  • Injury Prevention Center
  • Locations
  • Arkansas Children's App
  • Access MyChart
  • News
  • COVID-19 Resources
  • Support Groups & Resources
  • Employee Resources
  • En español
  • Contact Us
AR Childrens
ANCC Magnet Recognition logo Best Children's Hospitals - US News & World Report - Ranked in 7 Specialties 2022-23 CMNH logo

© 2023 Arkansas Children's. Privacy Policy | Terms of Use