Dr. Chintapalli seeks to understand the biochemical and cellular factors that underlie muscle function and fuel utilization with a specific focus on the role of myoglobin in this process. This research is important in discovering the underlying mechanisms involved with the positive health benefits of physical activity and exercise, which is important in children and adults alike. The degree to which myoglobin and other globin family proteins functionally respond to nutrition and fitness remains to be fully elucidated, and very little is known about these questions during development or pregnancy. His studies leverage structural, functional, and evolutionary biology using sequence analysis, molecular modeling, protein structure prediction, and protein-protein and protein-ligand interactions using Docking and molecular dynamic simulations. As part of the Informatics Team at the Arkansas Children’s Nutrition Center, Dr. Chintapalli works with investigators to perform bioinformatics analysis of RNA-Seq data, microbial and metagenomics analysis.