Hemoglobinopathies

Penicillin Prophylaxis is indicated

• FS Presumed sickle cell disease
• FSC, FCS Presumed sickle-hemoglobin C disease
• FSE Presumed sickle-hemoglobin E disease
• FSA Presumed sickle-β+-thalassemia

• Steps:
  • Contact parent/guardian to check on the health of the infant, and to explain these results.
  • Physicians please refer to attached newborn screening information sheet for interpretation of results.
  • Send whole blood for confirmatory electrophoresis at 2-3 months of age. Please fax a copy of the results to health department at 501-682-6686.
  • Penicillin prophylaxis should be started no later than 2 months of age.
  • It is recommended that primary care physicians refer infants to the Arkansas Children's Hospital Comprehensive Sickle Cell Clinic. Please call 364-1076 to set up an appointment.

No Antibiotic Prophylaxis is indicated.

• FC Presumed hemoglobin C disease
• FCA Presumed hemoglobin C-β+-thalassemia
• FE Presumed hemoglobin E disease
• F Fetal hemoglobin only - inconclusive

• Steps:
  • Contact parent/guardian to check on the health of the infant, and to explain these results.
  • Refer to attached newborn screening information sheet for interpretation of results.
  • Send whole blood for confirmatory electrophoresis at 2-3 months of age. Please fax a copy of the results to health department at 501-682-6686.
  • It is recommended that primary care physicians refer infants to the Arkansas Children's Hospital Comprehensive Sickle Cell Clinic. Please call 364-1076 to set up an appointment.

No Antibiotic Prophylaxis is indicated.

• FAS Presumed sickle trait
• AFS, ASF Presumed sickle trait; sickle disease not entirely excluded
• FAC Presumed hemoglobin C trait
• FAE Presumed hemoglobin E trait
• FAG Presumed hemoglobin G trait
• FAD Presumed hemoglobin D trait
• FA+Barts Presumed alpha-thalassemia trait (may be seen in conjunction with other traits and disease states)
• FA + unidentified Presumed trait for unidentified hemoglobin
• FA + fast Presumed trait for unidentified fast hemoglobin

• Steps:
  • The health department notifies the primary care provider by mail of the result, and encloses the interpretation sheet for hemoglobinopathy screening results.
  • The health department contacts the parent/guardian by mail to inform them of results and send a parent information sheet to them. For any questions, please contact the health department at 1-866-769-9043 OR call 501-364-4050 to speak with the Newborn Screening Coordinator.
  • For babies who received a blood transfusion prior to collection of their newborn screening, please refer to the health department letter for specific follow-up or contact the health department at 1-866-769-9034.

• If found within 3-4 months of a transfusion, this result is inconclusive.
• Otherwise, the result is presumed to be normal.

For any questions, please contact the health department at 1-866-769-9043 OR call 501-364-4050 to speak with the Newborn Screening Coordinator.

For more information, regarding Sickle Cell Trait, Alpha Thalassemia Trait or Trait for Unidentified Hemoglobin, please visit the ADH Website.